Mutum EGFR Gene 29 Maye gurbi

Ciwon daji na huhu ya zama babban sanadin mutuwar cutar kansa a duniya, yana yin barazana ga lafiyar dan adam.Ciwon daji na huhun da ba ƙaramin sel ba ya kai kusan kashi 80% na masu ciwon huhu.EGFR a halin yanzu shine mafi mahimmancin manufa ta kwayoyin don maganin ciwon daji na huhu mara karami.phosphorylation na EGFR na iya inganta haɓakar ƙwayar ƙwayar cuta, bambance-bambance, mamayewa, metastasis, anti-apoptosis, da haɓaka angiogenesis na ƙari.EGFR tyrosine kinase inhibitors (TKI) na iya toshe hanyar siginar EGFR ta hanyar hana EGFR autophosphorylation, ta haka ne ya hana haɓakawa da bambance-bambancen ƙwayoyin ƙwayar cuta, haɓaka apoptosis cell tumor, rage ƙwayar angiogenesis, da dai sauransu, don cimma nasarar maganin da aka yi niyya.Yawancin karatu sun nuna cewa tasirin maganin warkewa na EGFR-TKI yana da alaƙa da alaƙa da matsayin maye gurbi na EGFR, kuma yana iya hana haɓakar ƙwayoyin ƙwayar cuta musamman tare da maye gurbin EGFR.Halin EGFR yana kan guntun hannu na chromosome 7 (7p12), tare da cikakken tsawon 200Kb kuma ya ƙunshi 28 exons.Yankin da aka canza ya fi girma a cikin exon 18 zuwa 21, codons 746 zuwa 753 maye gurbi akan exon 19 yana da kusan kashi 45% kuma maye gurbin L858R akan exon 21 yana da kusan 40% zuwa 45%.Ka'idojin NCCN don Bincike da Magance Ciwon Kankara mara Karan Huhu ya bayyana a sarari cewa ana buƙatar gwajin maye gurbin EGFR kafin gudanar da EGFR-TKI.Ana amfani da wannan kit ɗin gwajin don jagorantar gudanarwar magungunan haɓakar haɓakar epidermal tyrosine kinase inhibitor (EGFR-TKI), da kuma samar da tushen maganin keɓaɓɓen magani ga marasa lafiya da ciwon huhu mara ƙanƙara.Ana amfani da wannan kit ɗin ne kawai don gano sauye-sauye na yau da kullun a cikin kwayar halittar EGFR a cikin marasa lafiya da ciwon huhu mara ƙanƙanta.Sakamakon gwajin don nunin asibiti ne kawai kuma bai kamata a yi amfani da shi a matsayin tushen kawai don maganin keɓantaccen mutum na marasa lafiya ba.Ya kamata likitoci suyi la'akari da yanayin majiyyaci, alamun magunguna, da magani Ana amfani da amsawa da sauran alamun gwajin dakin gwaje-gwaje da wasu dalilai don yanke hukunci ga sakamakon gwajin.