Mycobacterium Tuberculosis Nucleic Acid da Rifampicin Resistance

Mycobacterium tarin fuka, jim kadan a matsayin Tubercle bacillus, tarin fuka, shine kwayoyin cutar da ke haifar da tarin fuka.A halin yanzu, magungunan da ake amfani da su na farko na maganin tarin fuka sun hada da isoniazid, rifampicin da hexambutol, da dai sauransu. Na biyu na maganin tarin fuka sun hada da fluoroquinolones, amikacin da kanamycin, da dai sauransu. Sabbin magungunan da aka samar sune linezolid, bedaquiline da delamani, da dai sauransu. Duk da haka, saboda rashin amfani da magungunan cutar tarin fuka da kuma halayen tsarin bangon tantanin halitta na mycobacterium tarin fuka, tarin fuka na mycobacterium yana haifar da juriya ga magungunan tarin fuka, wanda ke kawo kalubale mai tsanani ga rigakafi da maganin tarin fuka.

An yi amfani da Rifampicin sosai wajen kula da masu fama da cutar tarin fuka tun daga ƙarshen shekarun 1970, kuma yana da tasiri sosai.Ya kasance zaɓi na farko don taƙaita chemotherapy na masu cutar tarin fuka.Rifampicin juriya yana faruwa ne ta hanyar maye gurbin kwayar halittar rpoB.Duk da cewa sabbin magungunan cutar tarin fuka a kullum suna fitowa, kuma ingancin asibiti na masu fama da cutar tarin fuka shi ma ya ci gaba da inganta, har yanzu akwai karancin magungunan cutar tarin fuka, kuma al’amarin amfani da kwayoyi marasa ma’ana a asibiti yana da yawa.Babu shakka, cutar tarin fuka ta Mycobacterium da ke fama da ciwon huhu na huhu ba za a iya kashe shi gaba ɗaya cikin lokaci ba, wanda a ƙarshe yakan haifar da juriya na magunguna daban-daban a jikin majiyyaci, yana tsawaita tsawon lokacin cutar, kuma yana ƙara haɗarin mutuwar majiyyaci.