Mutum CYP2C9 da VKORC1 Gene Polymorphism

Takaitaccen Bayani:

Wannan kit ɗin yana da amfani ga in vitro qualitative detection of polymorphism na CYP2C9*3 (rs1057910, 1075A>C) da VKORC1 (rs9923231, -1639G>A) a cikin kwayar halittar DNA na samfuran jinin mutum duka.


Cikakken Bayani

Tags samfurin

Sunan samfur

HWTS-GE014A-Human CYP2C9 da VKORC1 Gene Polymorphism Gane Kit (Fluorescence PCR)

Takaddun shaida

CE

Epidemiology

Warfarin maganin maganin jini ne na baka wanda aka saba amfani dashi a aikin asibiti a halin yanzu, wanda aka yi niyya don rigakafi da magance cututtukan thromboembolic.Koyaya, warfarin yana da ƙayyadaddun taga magani kuma ya bambanta sosai tsakanin jinsi da daidaikun mutane daban-daban.Ƙididdiga sun nuna cewa bambancin barga a cikin mutane daban-daban na iya zama fiye da sau 20.Zubar da jini mara kyau yana faruwa a cikin 15.2% na marasa lafiya da ke shan warfarin kowace shekara, wanda kashi 3.5% ke haifar da zubar da jini mai mutuwa.Nazarin Pharmacogenomic sun nuna cewa polymorphism na kwayoyin halitta na manufa enzyme VKORC1 da kuma enzyme na rayuwa CYP2C9 na warfarin wani muhimmin abu ne wanda ke shafar bambancin kashi na warfarin.Warfarin shine takamaiman mai hana bitamin K epoxide reductase (VKORC1), don haka yana hana haɓakar abubuwan da ke tattare da ƙwayar cuta da ke tattare da bitamin K kuma yana ba da maganin hana jini.Yawancin karatu sun nuna cewa polymorphism na kwayar halitta na VKORC1 mai gabatarwa shine mafi mahimmancin abin da ya shafi tseren da bambance-bambancen mutum a cikin adadin da ake buƙata na warfarin.CYP2C9 ne ke daidaita Warfarin, kuma kwayoyin halittarsa ​​suna rage saurin warfarin.Mutanen da ke amfani da warfarin suna da haɗari mafi girma (sau biyu zuwa uku) na zubar jini a farkon matakin amfani.

Tashoshi

FAM VKORC1 (-1639G>A)
CY5 CYP2C9*3
VIC/HEX IC

Ma'aunin Fasaha

Adana Ruwa: ≤-18℃
Rayuwar rayuwa watanni 12
Nau'in Samfura Fresh EDTA anticoagulated jini
CV ≤5.0%
LoD 1.0ng/μL
Musamman Babu wani giciye-reactivity tare da wasu daidaitattun jerin kwayoyin halittar ɗan adam (jinin CYP2C19 ɗan adam, ɗan adam RPN2 gene);maye gurbin CYP2C9*13 da VKORC1 (3730G>A) a waje da kewayon gano wannan kit ɗin.
Abubuwan da ake Aiwatar da su Abubuwan da aka Aiwatar da Biosystems 7500 Tsarin PCR na Gaskiya

Abubuwan da aka Aiwatar da Tsarin Halittu 7500 Tsarin PCR Mai Saurin Real-Time

QuantStudio®5 Tsarin PCR na Gaskiya

SLAN-96P Tsarin PCR na Gaskiya

LightCycler®480 Tsarin PCR na Gaskiya

LineGene 9600 Plus Tsarin Gane PCR na Gaskiya

MA-6000 Mai ƙididdige yawan zafin jiki na ainihi

BioRad CFX96 Tsarin PCR na Gaskiya

BioRad CFX Opus 96 Tsarin PCR na Gaskiya

Gudun Aiki

Shawarar hakar reagent: Macro & Micro-Test Viral DNA/RNA Kit(HWTS-3001, HWTS-3004-32, HWTS-3004-48, HWTS-3004-96) da Macro & Micro-Test Atomatik Nucleic Acid Extractor(HWTS- 3006).


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